Research
Undergraduate Researcher - He Laboratory • (8/2023-Present)
Undergraduate Researcher
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PI: Dr. Mei He
Department: Pharmacy
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Designed, printed, and bonded microfluidic devices.
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Worked on hydrogel 3D bioprinting.
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Self-Lead Project for publication and Senior Honors Thesis.
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Second Author for Project: “High-Throughput Generation of Collagen Microbioreactors for 3D Cell
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Culture and Extracellular Vesicle Production.”
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Link to preprint: https://pmc.ncbi.nlm.nih.gov/articles/PMC11566015/.
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Drafting review paper: Developmental biology extracellular vesicles and their multiple applications.
Summer Research Internship – Menglu Yang Lab and Fei Liu Lab – Massachusetts Eye and Ear Research Hospital
and Harvard Brigham Women’s Hospital • (6/205-8/2025)
Undergraduate Researcher
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PI: Dr. Menglu Yang
Department: Ophthalmology
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Aided in extraction of tear extracellular vesicles via EXODUS isolation system.
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EV sample protein fragmentation for subsequent proteomics analysis.
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EV sample DNA extraction.
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Performed neuron cell culture and immunohistochemistry.
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Currently drafting first author review paper about bioengineering in the eye.
Bovine placental-derived bio-Ink
reprograms tissue microenvironment for enhanced regeneration and senescence reversal
Project Leader
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Optimized extraction process of COL 1 from dissected bovine placenta to obtain higher purity and yield compared to market collagen.
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Successfully extracted and characterized amniotic fluid EVs and established EXODUS as method that leads to purer and higher yield extractions than ultracentrifugation.
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Confirmed biocompatibility and highly regenerative properties of placental collagen and amniotic fluid EVs through scratch assays and presto blue assays.
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Established anti-senescent properties of AF-EVs through senescence marker staining and imaging.
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Leveraged microfluidic device-based spheroid embedding for encapsulating AF-EVs within placental collagen droplets for sustained release into the wound microenvironment for reprogramming and senescence reversal.
